Fredericktown, MO

ZIP code 63645 serves Fredericktown, the county seat of Madison County in southeastern Missouri. Its central landmarks include the Madison County Courthouse and the historic downtown around the courthouse square. Outdoor destinations in the area include Millstream Gardens Conservation Area, known for the St. Francis River’s rocky channels, and Amidon Memorial Conservation Area, which protects wooded hills and the Castor River’s granite shut-ins.